反应详情

To a solution of the product of Part (B) (0.42 g, 1.0 mMole) in methylene chloride (5 ml) at -72° was added m-chloroperbenzoic acid (0.32 g, 1.5 mMole) in three equal portions over a twelve minute period. Two hours later the mixture, at -70°, was poured into an aqueous solution of saturated sodium bicarbonate and sodium sulphite (20 ml) with vigorous stirring. The organic layer was separated, washed with saturated sodium bicarbonate (3×5 ml) and water (3×5 ml), and dried over anhydrous sodium sulphate. Evaporation gave the title compound as an oil, 0.20 g, (74% yield). The compound was used directly in the next stage.

1. customThe organic layer was separated
2. washwashed with saturated sodium bicarbonate (3×5 ml) and water (3×5 ml)
3. dry with materialdried over anhydrous sodium sulphate
4. customEvaporation