Ethylamine → HCID 14648900, compound

HRID 2291396Notes

Reaction equation

HRID 2291396 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2([C:18]#[N:19])[CH2:16][CH2:15][C:14](=O)[CH2:13][CH2:12]2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].C(N(CC)CC)C.[ClH:27].[CH2:28]([NH:30][CH:31]1[CH2:40][CH2:39][C:38]2[C:33](=[CH:34][CH:35]=[CH:36][CH:37]=2)[CH2:32]1)[CH3:29].C1C2C(=CC=CC=2)CCC1=O.C(N)C.[Na]>C(O)C>[ClH:27].[CH2:32]1[C:33]2[C:38](=[CH:37][CH:36]=[CH:35][CH:34]=2)[CH2:39][CH2:40][CH:31]1[N:30]([CH2:28][CH3:29])[CH:14]1[CH2:15][CH2:16][C:11]([C:5]2[CH:6]=[CH:7][C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=2)([C:18]#[N:19])[CH2:12][CH2:13]1

Participants

8

Reactant 6

HCID 6341EthylamineHCID 8471TriethylamineHCID 682662-TetraloneHCID 749913Cyclohexanecarbonitrile, 1-(3,4-dimethoxyphenyl)-4-oxo-HCID 5360545SodiumHCID 1284307522583-91-1

Product 1

HCID 14648900HCID 14648900, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 4-(3,4-dimethoxyphenyl)-4-cyanocyclohexanone (3 mmol), triethylamine (3 mmol), 2-ethylamino-1,2,3,4-tetrahydronaphthalene hydrochloride prepared by reductive amination of 3,4-dihydro-2-(1H)-naphthalenone with ethylamine and sodium cyanoborhydride, (3 mmol) in ethanol was stirred 72 hours and worked up as in Example 17. ##STR22##

Sources & evidence

ORD record
ord-aea211041d36403498231e5281873087
Source dataset
uspto-grants-1989_01
Patent number
US04795757

Reaction notes

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