Dimethylformamide dimethyl acetal → HCID 15595573, compound

HRID 2291450Notes

Reaction equation

HRID 2291450 reaction equation
[Cl:1][C:2]1[C:11]([C:12]([NH2:14])=[O:13])=[C:10]2[C:5]([CH:6]=[C:7]([CH3:15])[CH:8]=[N:9]2)=[CH:4][CH:3]=1.CO[CH:18](OC)[N:19]([CH3:21])[CH3:20]>CN(C)C=O>[CH3:18][N:19]([CH3:21])[CH:20]=[N:14][C:12]([C:11]1[C:2]([Cl:1])=[CH:3][CH:4]=[C:5]2[C:10]=1[N:9]=[CH:8][C:7]([CH3:15])=[CH:6]2)=[O:13]

Participants

4

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 14125865HCID 14125865, compound

Product 1

HCID 15595573HCID 15595573, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

55.1 g (0.25 mole) of 7-chloro-3-methylquinoline-8-carboxamide were dissolved in 50 ml of N,N-dimethylformamide, 39.3 g (0.32 mole) of N,N-dimethylformamide dimethyl acetal were added, and the mixture was refluxed for 4 hours. After precipitation on ether, 44.0 g (64%) of colorless crystals of melting point 183°-185° C. (decomposition) were isolated (compound No. 22).

Workup

  1. temperaturethe mixture was refluxed for 4 hours
  2. customAfter precipitation on ether, 44.0 g (64%) of colorless crystals of melting point 183°-185° C. (decomposition)
  3. customwere isolated (compound No. 22)

Sources & evidence

ORD record
ord-2e0288ba578f45a3a605b89c12473136
Source dataset
uspto-grants-1989_01
Patent number
US04797148

Reaction notes

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