Diethylamine → HCID 14013804, compound

HRID 2291480Notes

Reaction equation

HRID 2291480 reaction equation
Cl[C:2]1[C:7]([C:8]([O:10][CH3:11])=[O:9])=[C:6]([C:12]([Cl:15])([F:14])[F:13])[N:5]=[C:4]([C:16]([F:19])([F:18])[F:17])[C:3]=1[C:20]([O:22][CH2:23][CH3:24])=[O:21].[CH2:25]([NH:27][CH2:28][CH3:29])[CH3:26]>CN(C=O)C>[Cl:15][C:12]([F:13])([F:14])[C:6]1[N:5]=[C:4]([C:16]([F:19])([F:18])[F:17])[C:3]([C:20]([O:22][CH2:23][CH3:24])=[O:21])=[C:2]([N:27]([CH2:28][CH3:29])[CH2:25][CH3:26])[C:7]=1[C:8]([O:10][CH3:11])=[O:9]

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 140137593-Ethyl 5-methyl 4-chloro-6-(chlorodifluoromethyl)-2-(trifluoromethyl)-3,5-pyridinedicarboxylate

Product 1

HCID 14013804HCID 14013804, compoundYield 82.3%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

This compound was prepared as described in Example 37: 5.0 g (0.013 mol) of product of Example 28, 2.6 ml (0.025 mol) of diethylamine in 25 ml of DMF were reacted at room temperature for 16 hours affording a yellow semi-solid oil which was kugelrohr distilled at 80 Pa, pot temperature 102°-105° C. , to give 4.63 g (82.3%) of product as a yellow solid; mp 31.5°-33° C.

Workup

  1. customThis compound was prepared
  2. customaffording a yellow semi-solid oil which
  3. distillationwas kugelrohr distilled at 80 Pa, pot temperature 102°-105° C.

Sources & evidence

ORD record
ord-f23bf3002c734b7eb14baaf101a78d0b
Source dataset
uspto-grants-1989_01
Patent number
US04797149

Reaction notes

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