Isopropanol → HCID 131720266, compound

HRID 2292513Notes

Reaction equation

HRID 2292513 reaction equation
[CH3:1][C:2]1[N:6]2[C:7]3[CH:38]=[CH:37][CH:36]=[CH:35][C:8]=3[N:9]([CH2:12][CH2:13][CH2:14][N:15]3[CH2:20][CH2:19][N:18]([CH:21]([C:28]4[CH:33]=[CH:32][C:31]([Cl:34])=[CH:30][CH:29]=4)[C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[CH2:17][CH2:16]3)[CH2:10][CH2:11][C:5]2=[N:4][N:3]=1.[C:39]([OH:46])(=[O:45])/[CH:40]=[CH:41]/[C:42]([OH:44])=[O:43].C(O)(C)C.C(OC(C)C)(C)C>CO>[C:39]([OH:46])(=[O:45])/[CH:40]=[CH:41]/[C:42]([OH:44])=[O:43].[CH3:1][C:2]1[N:6]2[C:7]3[CH:38]=[CH:37][CH:36]=[CH:35][C:8]=3[N:9]([CH2:12][CH2:13][CH2:14][N:15]3[CH2:16][CH2:17][N:18]([CH:21]([C:28]4[CH:29]=[CH:30][C:31]([Cl:34])=[CH:32][CH:33]=4)[C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[CH2:19][CH2:20]3)[CH2:10][CH2:11][C:5]2=[N:4][N:3]=1

Participants

6

Reactant 4

HCID 3776IsopropanolHCID 7914Diisopropyl EtherHCID 444972Fumaric AcidHCID 21478661HCID 21478661, compound

Product 1

HCID 131720266HCID 131720266, compoundYield 34.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To a solution containing 0.26 g of the compound of Example 214 in methanol, 59 mg of fumaric acid in methanol is added and the resulting mixture is condensed. To the resultant, isopropanol and isopropyl ether are added. The resultant is subjected to filtration and the filtrate is dried to obtain 0.11 g of (214) in the form of amorphous.

Workup

  1. additionis added
  2. customcondensed
  3. filtrationThe resultant is subjected to filtration
  4. customthe filtrate is dried

Sources & evidence

ORD record
ord-800e99d3ac034986b19f31a8fa8a364c
Source dataset
uspto-grants-1997_11
Patent number
US05683998

Reaction notes

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