Anthranilic Acid → HCID 178518333, Verbindung

HRID 2293137Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2293137
[NH2:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].[O-:11][C:12]#[N:13].[K+].[OH-].[Na+].Cl>O.C(O)(=O)C>[OH:11][C:12]1[N:13]=[C:4]([OH:5])[C:3]2[C:2](=[CH:10][CH:9]=[CH:8][CH:7]=2)[N:1]=1

Komponenten

7

Edukt 4

HCID 227Anthranilic AcidHCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 11378442Potassium cyanate

Produkt 1

HCID 178518333HCID 178518333, VerbindungAusbeute 90,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittelHCID 962WaterLösungsmittel2×

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

To a mixture containing 41 g of 2-aminobenzoic acid (0.3M), 21 of water and 34 ml of acetic acid, was dropwise added 54 g of potassium cyanate dissolved in 200 ml of water. The resultant was stirred for an hour and slowly added with 60 g of 0.3M aqueous sodium hydroxide so as not to exceed the reaction temperature of 40° C. The solution, while heated to 90° C., was stirred for 30 minutes, and then cooled to 0° C. The resultant was acidified by adding a concentrated hydrochloric acid and the solids thus produced were filtered to obtain 43.7 g of the title compound.

Aufarbeitung

  1. customthe reaction temperature of 40° C
  2. stirringwas stirred for 30 minutes
  3. temperaturecooled to 0° C
  4. customthe solids thus produced
  5. filtrationwere filtered

Quellen und Nachweise

ORD-Eintrag
ord-c56e3f5695b64ff6a869326b8e4a82da
Quelldatensatz
uspto-grants-1997_11
Patentnummer
US05686458

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