3-(Trifluoromethyl)phenol → HCID 21471072, compound

HRID 2294775Notes

Reaction equation

HRID 2294775 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([C:15]#[N:16])[CH:12]=[C:11](Cl)[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:18][C:19]([F:28])([F:27])[C:20]1[CH:21]=[C:22]([OH:26])[CH:23]=[CH:24][CH:25]=1.C(=O)([O-])[O-].[K+].[K+]>CN1CCCC1=O>[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([C:15]#[N:16])[CH:12]=[C:11]([O:26][C:22]2[CH:23]=[CH:24][CH:25]=[C:20]([C:19]([F:18])([F:27])[F:28])[CH:21]=2)[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 73763-(Trifluoromethyl)phenolHCID 11430Potassium CarbonateHCID 21471067HCID 21471067, compound

Product 1

HCID 21471072HCID 21471072, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

2-Benzyloxy-6-chloro-4-cyanopyridine (0.8 g, 0.0033 mol) and meta-trifluoromethyl phenol (0.58 g, 0.0033×1.1 mol) were dissolved in 20 ml of N-methyl-pyrrolidinone, and anhydrous potassium carbonate (0.5 g, 0.0033×1.1 mol) was added thereto and the resultant solution was stirred for about 2.5 hours at about 100° C.

Sources & evidence

ORD record
ord-04800fee43ac4f0b92e366a10f279013
Source dataset
uspto-grants-1997_11
Patent number
US05691277

Reaction notes

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