反应详情

To meta-trifluoromethyl phenol (2.5 g, 0.0028×5.5 mol), 15 ml of dimethylformamide was added, followed by the addition of sodium hydride (0.45 g (ca.60% in mineral oil), 0.0028×4.0 mol) and CuI (0.25 g, 0.0028×0.47 mol). To thus formed mixture was added 2,6-dichloro-4-methoxy-pyridine (0.5 g, 0.0028 mol), and the resultant solution was refluxed for about 8 hours.