反应详情

A mixture of benzyl 6-(1-hydroxyethyl)-3-toluenesulfonyloxy-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylate (46 mg) N-methyl-N-(2-dimethylaminoethyl)amine (10.2 mg), and triethylamine (28 μl) in anhydrous DMF (0.5 ml) is stirred at room temperature for 4 hrs. The mixture is diluted with ethyl acetate (10 ml) washed with H2O (5×2 ml) and brine, dried with MgSO4, filtered and evaporated in vacuo to provide benzyl 6-(1-hydroxyethyl)-3-[N-methyl-N-(2-dimethylaminoethyl)amino]-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylate.

1. washwashed with H2O (5×2 ml) and brine
2. dry with materialdried with MgSO4
3. filtrationfiltered
4. customevaporated in vacuo