反应详情

To 20 ml of tetrahydrofuran were added 2.4 g of 4-amino-6,7-dimethoxy-2-(1-piperazinyl)quinazoline hydrochloride and 2.6 g of triethylamine, after which the mixture was stirred for 30 minutes. There was then added 0.6 g of 2-methylacryloyl chloride, after which the mixture was stirred at room temperature for 8 hours. The crystals which were produced were collected by filtration, washed with water and recrystallized from ethanol to give 0.8 g of the desired Compound No. 2 in the form of colourless needles melting at 262°-263° C. (with decomposition).

1. stirringafter which the mixture was stirred at room temperature for 8 hours
2. customThe crystals which were produced
3. filtrationwere collected by filtration
4. washwashed with water
5. customrecrystallized from ethanol