Sodium hydride → HCID 69831222, compound

HRID 2297505Notes

Reaction equation

HRID 2297505 reaction equation
Cl[C:2]1[C:11]2[C:6](=[C:7]([C:14]#[C:15][C:16]3[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=3)[C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[CH:5]=[N:4][N:3]=1.[Cl:22][C:23]1[CH:24]=[N:25][CH:26]=[C:27]([Cl:30])[C:28]=1[CH3:29].[H-].[Na+]>CN(C=O)C>[Cl:22][C:23]1[CH:24]=[N:25][CH:26]=[C:27]([Cl:30])[C:28]=1[CH2:29][C:2]1[C:11]2[C:6](=[C:7]([C:14]#[C:15][C:16]3[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=3)[C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[CH:5]=[N:4][N:3]=1

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 109538273,5-Dichloro-4-methylpyridineHCID 53820011HCID 53820011, compound

Product 1

HCID 69831222HCID 69831222, compoundYield 40.4%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Operating analogously to what described in example 15 starting from 1-chloro-6-methoxy-5-pyridin-4-ylethynyl-phthalazine (1.38 g, 4.66 mmoles), prepared as described in example 142, 3,5-dichloro-4-methylpyridine (1.887 mg, 11.65 mmoles), DMF (20 ml), NaH (466 mg, 11.65 mmoles), 793 mg of the title compound were obtained.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-c5b0ffe83d314876bcad5a5848c77e5d
Source dataset
uspto-grants-2002_12
Patent number
US06492360B1

Reaction notes

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