Tetrahydrofuran → HCID 86758638, compound

HRID 2297520Notes

Reaction equation

HRID 2297520 reaction equation
[C:1]12[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=1)[NH:6][C:5](=[O:12])OC2=O.[NH2:13]CCCO.[O:18]1[CH2:22][CH2:21][CH2:20][CH2:19]1>>[OH:18][CH2:19][CH2:20][CH2:21][CH2:22][N:6]([C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][C:1]=1[NH2:13])[CH:5]=[O:12]

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 8359Isatoic AnhydrideHCID 90863-Amino-1-propanol

Product 1

HCID 86758638HCID 86758638, compoundYield 82%

Procedure

Isatoic anhydride (4.5 g), 3-aminopropanol (2.66 ml) were added to tetrahydrofuran (70 ml), and the mixture was stirred at room temperature for 4 hours. Tetrahydrofuran was removed and the residue was purified by silica gel column chromatography (ethyl acetate) to obtain 4.7 g of N-(4-hydroxybutyl)(2-aminophenyl)formamide. Yield: 82%.

Workup

  1. customTetrahydrofuran was removed
  2. customthe residue was purified by silica gel column chromatography (ethyl acetate)

Sources & evidence

ORD record
ord-652bc817a9b547d9aadc649c98bc0a46
Source dataset
uspto-grants-2002_12
Patent number
US06492364B1

Reaction notes

Loading…