反应详情

温度

80 °C

Diphenylmethylpiperazine (2.20 g) was dissolved in dimethylformamide (25 ml), and then 1-chloro-3-pentanol (1.78 g) and potassium carbonate (722 mg) were added thereto, followed by stirring the mixture at 80° C. for 15 hours. After evaporation of dimethylformamide, water was added to the residue and the resultant was extracted 3 times with ethyl acetate. Organic layers were combined and washed with brine. The resultant was dried over anhydrous sodium sulfate and concentrated. The residue was purified by silica gel column chromatography (ethyl acetate) to obtain 1.79 g of amorphous 1-(4-(diphenylmethyl)piperazinyl)pentane-3-ol. Yield: 61%.

1. customAfter evaporation of dimethylformamide, water
2. additionwas added to the residue
3. extractionthe resultant was extracted 3 times with ethyl acetate
4. washwashed with brine
5. dry with materialThe resultant was dried over anhydrous sodium sulfate
6. concentrationconcentrated
7. customThe residue was purified by silica gel column chromatography (ethyl acetate)