Hydrochloric Acid → (1H-Indol-5-yl)-[6-(4-methylaminomethyl-phenyl)-thieno[3,2-d]pyrimidin-4-yl]-amine

HRID 2297773Notes

Reaction equation

[CH3:1][NH2:2].[NH:3]1[C:11]2[C:6](=[CH:7][C:8]([NH:12][C:13]3[C:14]4[S:21][C:20]([C:22]5[CH:29]=[CH:28][C:25]([CH:26]=O)=[CH:24][CH:23]=5)=[CH:19][C:15]=4[N:16]=[CH:17][N:18]=3)=[CH:9][CH:10]=2)[CH:5]=[CH:4]1.Cl>>[NH:3]1[C:11]2[C:6](=[CH:7][C:8]([NH:12][C:13]3[C:14]4[S:21][C:20]([C:22]5[CH:29]=[CH:28][C:25]([CH2:26][NH:2][CH3:1])=[CH:24][CH:23]=5)=[CH:19][C:15]=4[N:16]=[CH:17][N:18]=3)=[CH:9][CH:10]=2)[CH:5]=[CH:4]1

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 6329Methylamine

HCID 183827594-(4-(1H-indol-5-ylamino)-thieno[3,2-d]pyrimidin-6-yl]-benzaldehyde

Product 1

HCID 18382985(1H-Indol-5-yl)-[6-(4-methylaminomethyl-phenyl)-thieno[3,2-d]pyrimidin-4-yl]-amine

Procedure

The title compound was prepared from methylamine and 4-[4-(1H-indol-5-ylamino)-thieno[3,2-d]pyrimidin-6-yl]-benzaldehyde by a procedure analogous to example 17. The product was converted to the mesylate salt analogous to example 17 being converted to the HCl salt. M.P. 140-147° C.; LC-MS: 386 (MH−); HPLC RT: 3.54 minutes.

Sources & evidence

ORD record: ord-6d69ce6f5bfa4750a8f480b9b61f6296
Source dataset: uspto-grants-2002_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06492383B1

Reaction notes

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