Hydrochloric Acid → HCID 18382988, compound

HRID 2297776Notes

Reaction equation

HRID 2297776 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][OH:5].[NH:6]1[C:14]2[C:9](=[CH:10][C:11]([NH:15][C:16]3[C:17]4[S:24][C:23]([C:25]5[CH:32]=[CH:31][C:28]([CH:29]=O)=[CH:27][CH:26]=5)=[CH:22][C:18]=4[N:19]=[CH:20][N:21]=3)=[CH:12][CH:13]=2)[CH:8]=[CH:7]1.Cl>>[NH:6]1[C:14]2[C:9](=[CH:10][C:11]([NH:15][C:16]3[C:17]4[S:24][C:23]([C:25]5[CH:32]=[CH:31][C:28]([CH2:29][NH:1][CH2:2][CH2:3][CH2:4][OH:5])=[CH:27][CH:26]=5)=[CH:22][C:18]=4[N:19]=[CH:20][N:21]=3)=[CH:12][CH:13]=2)[CH:8]=[CH:7]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 90863-Amino-1-propanolHCID 183827594-(4-(1H-indol-5-ylamino)-thieno[3,2-d]pyrimidin-6-yl]-benzaldehyde

Product 1

HCID 18382988HCID 18382988, compound

Procedure

The title compound was prepared from 3-aminopropanol and 4-[4-(1H-indol-5-ylamino)-thieno[3,2-d]pyrimidin-6-yl]-benzaldehyde by a procedure analogous to example 17. The product was converted to the mesylate salt analogous to example 17 being converted to the HCl salt. 1H NMR (400 MHz, DMSO) d 11.1 (s, 1H), 9.54 (s, 1H), 8.44 (s, 1), 7.75 (dd, 4H), 7.42 (m, 4H), 7.23 (m, 1H), 6.41 (s, 1H), 3.67 (s, 2H), 3.43 (s, 2H), 3.30 (s, 2H), 1.54 (m, 2H); LC-MS: 430 (MH+); HPLC RT: 3.34 minutes.

Sources & evidence

ORD record
ord-9a68042896d740a785d5ef1061f5dc3c
Source dataset
uspto-grants-2002_12
Patent number
US06492383B1

Reaction notes

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