1,1'-Carbonyldiimidazole → HCID 57022441, compound

HRID 2298102Notes

Reaction equation

HRID 2298102 reaction equation
[C:1]([C:4]1[CH:5]=[C:6]([N:11]2[CH2:17][CH2:16][CH2:15][N:14]([C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH2:13][CH2:12]2)[CH:7]=[CH:8][C:9]=1[Cl:10])([OH:3])=O.C(N1C=CN=C1)(N1C=CN=C1)=O.Cl.[C:38]12([CH2:48][CH2:49][NH2:50])[CH2:47][CH:42]3[CH2:43][CH:44]([CH2:46][CH:40]([CH2:41]3)[CH2:39]1)[CH2:45]2.C(N(CC)C(C)C)(C)C>CN(C)C=O.O>[Cl:10][C:9]1[CH:8]=[CH:7][C:6]([N:11]2[CH2:17][CH2:16][CH2:15][N:14]([C:18]([O:20][C:21]([CH3:22])([CH3:24])[CH3:23])=[O:19])[CH2:13][CH2:12]2)=[CH:5][C:4]=1[C:1]([NH:50][CH2:49][CH2:48][C:38]12[CH2:47][CH:42]3[CH2:43][CH:44]([CH2:46][CH:40]([CH2:41]3)[CH2:39]1)[CH2:45]2)=[O:3]

Participants

7

Reactant 4

HCID 682631,1'-CarbonyldiimidazoleHCID 81531DiisopropylethylamineHCID 27711382-(Adamantan-1-yl)ethan-1-amine hydrochlorideHCID 86758643HCID 86758643, compound

Product 1

HCID 57022441HCID 57022441, compoundYield 49.2%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

A solution of 4-(3-carboxy-4-chlorophenyl)hexahydro-1H-1,4-diazepine-1-carboxylic acid, 1,1-dimethylethyl ester (0.075 g, Example 5b) and 1,140 -carbonyldiimidazole (0.034 g) in dimethylformamide (3 ml) was stirred at room temperature of 2.5 h. Tricyclo[3.3.1.13,7]decane-1-ethanamine, hydrochloride salt (0.045 g) and N,N-diisopropylethylamine (0.037 ml) were then added and stirring continued for 14 h. The reaction mixture was poured into water and extracted with ethyl acetate three times. The ethyl acetate layers were combined and washed with 2M hydrochloric acid, 10% aqueous sodium hydroxide and brine, then dried over magnesium sulfate and concentrated under reduced pressure. Purification by chromatography on silica gel eluting with 20% ethyl acetate in iso-hexane gave the subtitle compound as a yellow oil (0.053 g).

Workup

  1. extractionextracted with ethyl acetate three times
  2. washwashed with 2M hydrochloric acid, 10% aqueous sodium hydroxide and brine
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated under reduced pressure
  5. customPurification by chromatography on silica gel eluting with 20% ethyl acetate in iso-hexane

Sources & evidence

ORD record
ord-1fb2503b492e43b39c804f8a256cca37
Source dataset
uspto-grants-2002_12
Patent number
US06492355B1

Reaction notes

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