反应详情

To 4-methoxy-2-nitroaniline (10 mmol, 1.68 g) in 20 mL of DMF was added NaH (12 mmol, 480 mg of a 60% dispersion in mineral oil) (exothermic, H2 evolution), affording a deep red slurry. After 15 min MeI (20 mmol, 1.2 mL) was added (exothermic). After 30 min the reaction was poured into a solution of brine and NaHCO3, resulting in formation of a bright orange precipitate. The slurry was filtered and the filter cake was washed with H2O. The solid was dried under reduced pressure, affording a bright orange solid. HPLC A: 1.77 min.

1. customaffording a deep red slurry
2. customresulting in formation of a bright orange precipitate
3. filtrationThe slurry was filtered
4. washthe filter cake was washed with H2O
5. customThe solid was dried under reduced pressure
6. customaffording a bright orange solid
7. custom1.77 min.