Propylamine → HCID 17927876, compound

HRID 2301585Notes

Reaction equation

[Cl:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4]([Cl:11])[C:3]=1[S:12](Cl)(=[O:14])=[O:13].[CH2:16]([NH2:19])[CH2:17][CH3:18].C(N(CC)CC)C>>[CH2:16]([NH:19][S:12]([C:3]1[C:4]([Cl:11])=[CH:5][CH:6]=[C:7]([N+:8]([O-:10])=[O:9])[C:2]=1[Cl:1])(=[O:14])=[O:13])[CH2:17][CH3:18]

Participants

Reactant 3

HCID 7852Propylamine

HCID 8471Triethylamine

HCID 234477722,6-Dichloro-3-nitrobenzene-1-sulfonyl chloride

Product 1

HCID 17927876HCID 17927876, compoundYield 712.8%

Procedure

Following the general procedure for sulfonamide formation outlined in example 15, 2,6-dichloro-3-nitrobenzenesulfonyl chloride (1.3 g, 4.48 mmol), propylamine (264 mg, 4.48 mmol) and triethylamine(0.94mL, 6.72 mmol) were reacted to form the desired product (10 g, 71%). 1H NMR (MeOD-d4): δ7.92 (d, 1H), 7.78 (d, 1H), 3.00 (t, 2H), 1.50 (m, 2H), 0.88 (t, 3H).

Workup

customwere reacted

Sources & evidence

ORD record: ord-abfd8703908049d79458040cb67a56c9
Source dataset: uspto-grants-2002_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06500863B1

Reaction notes

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