Triethylamine → HCID 86588373, compound

HRID 2301611Notes

Reaction equation

HRID 2301611 reaction equation
[Cl:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4]([Cl:11])[C:3]=1[S:12](Cl)(=[O:14])=[O:13].[NH:16]1[CH2:20][CH2:19][CH2:18][CH2:17]1.C([N:23](CC)CC)C>>[N:16]1([C:6]2[CH:5]=[C:4]([Cl:11])[C:3]([S:12]([NH2:23])(=[O:14])=[O:13])=[C:2]([Cl:1])[C:7]=2[N+:8]([O-:10])=[O:9])[CH2:20][CH2:19][CH2:18][CH2:17]1

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 31268PyrrolidineHCID 234477722,6-Dichloro-3-nitrobenzene-1-sulfonyl chloride

Product 1

HCID 86588373HCID 86588373, compoundYield 68%

Procedure

Following the general procedure for sulfonamide formation outlined in example 15, 2,6-dichloro-3-nitrobenzenesulfonyl chloride (151 g, 5.2 mmol), pyrrolidine (435 μL, 5.2 mmol) and triethylamine(1.1 mL, 7.8 mmol) were reacted to form the desired product (1.16 g, 68%). LC-MS m/z 325(M+).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-5a5db6db83b84164a6f95d78da205359
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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