4-Aminopyridine → HCID 18373479, compound

HRID 2301614Notes

Reaction equation

HRID 2301614 reaction equation
[Cl:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4]([Cl:11])[C:3]=1[S:12](Cl)(=[O:14])=[O:13].[NH2:16][C:17]1[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=1.C(N(CC)CC)C>>[N:20]1[CH:21]=[CH:22][C:17]([NH:16][S:12]([C:3]2[C:4]([Cl:11])=[CH:5][CH:6]=[C:7]([N+:8]([O-:10])=[O:9])[C:2]=2[Cl:1])(=[O:14])=[O:13])=[CH:18][CH:19]=1

Participants

4

Reactant 3

HCID 17274-AminopyridineHCID 8471TriethylamineHCID 234477722,6-Dichloro-3-nitrobenzene-1-sulfonyl chloride

Product 1

HCID 18373479HCID 18373479, compoundYield 76%

Procedure

Following the general procedure for sulfonamide formation outlined in example 15, 2,6-dichloro-3-nitrobenzenesulfonyl chloride (500 mg, 1.72 mmol), 4-aminopyridine (165 mg,1.75 mmol) and triethylamine (0.36mL,2.58 mmol) were reacted to form the desired product (446 mg, 76%). EI-MS m/z 346(M-H)−.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-248108dc7ab04ba0bd11116b775dbfa6
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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