反应详情

To a solution of 476 mg (1.42 mmol) of 1-benzyloxycarbonyl-4-(t-butoxycarbonylamino)piperidine from Step B and 0.24 mL (2.8 mmol) of ethyl iodide in 10 mnL of DMF was added 85 mg (2.1 mmol) of 60% sodium hydride in mineral oil. The reaction was stirred for 16 h and was then poured into water and extracted three times with ether. The organic layers were each washed with a portion of water and brine, dried over sodium sulfate, combined and concentrated. The residue was purified by FC eluting with 15% ethyl acetate in hexanes to afford 409 mg of title compound.

1. extractionextracted three times with ether
2. washeach washed with a portion of water and brine
3. dry with materialdried over sodium sulfate
4. concentrationconcentrated
5. customThe residue was purified by FC
6. washeluting with 15% ethyl acetate in hexanes