反应详情

温度

50 °C

A solution of quinoline-4-carboxylic acid (173 mg, 1 mmol), and 1,1′-carbonyldiimidazole (162 mg, 1 mmol) in dimethylformamide (2 mL) was heated at 50° C. for 1 hour. After this time, trans-4-methylcyclohexylamine hydrochloride (150 mg, 1 mmol), and N,N-diisopropylethylamine (0.262 mL, 1.5 mmol) were added and the mixture heated at 50° C. for 16 hours. The reaction mixture was cooled, and diluted with chloroform (10 mL). The organic solution was washed with water (3×10 mL), 1 N NaOH (10 mL), brine (10 mL), dried over anhydrous MgSO4, filtered and concentrated to afford 156 mg (58%) of 403:

1. temperatureThe reaction mixture was cooled
2. washThe organic solution was washed with water (3×10 mL), 1 N NaOH (10 mL), brine (10 mL)
3. dry with materialdried over anhydrous MgSO4
4. filtrationfiltered
5. concentrationconcentrated