Hydrochloric Acid → HCID 11727658, compound

HRID 2302140Notes

Reaction equation

HRID 2302140 reaction equation
[Cl:1][C:2]1[C:11]([CH2:12][O:13][C:14]2[N:18]([CH3:19])[N:17]=[CH:16][CH:15]=2)=[C:10]([S:20]([CH3:23])(=[O:22])=[O:21])[CH:9]=[CH:8][C:3]=1[C:4]([O:6]C)=[O:5].[OH-].[Li+].Cl>O1CCCC1.O>[Cl:1][C:2]1[C:11]([CH2:12][O:13][C:14]2[N:18]([CH3:19])[N:17]=[CH:16][CH:15]=2)=[C:10]([S:20]([CH3:23])(=[O:21])=[O:22])[CH:9]=[CH:8][C:3]=1[C:4]([OH:6])=[O:5]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 70148215HCID 70148215, compound

Product 1

HCID 11727658HCID 11727658, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

6.95 g (19 mmol) of methyl 2-chloro-[(1-methylpyrazol-5-yl)oxymethyl]-4-methylsulfonylbenzoate in a mixture of 30 ml of tetrahydrofurane and 30 ml of water are treated at room temperature with 0.93 g of lithium hydroxide for 12 h. The reaction mixture is adjusted to pH4 with 10% strength hydrochloric acid and extracted with methylene chloride. The organic phase is dried and freed from the solvent. Yield: 4.3 g; m.p. 197° C.

Workup

  1. extractionextracted with methylene chloride
  2. customThe organic phase is dried

Sources & evidence

ORD record
ord-b51555d2d172446fbed19c89e5761ca4
Source dataset
uspto-grants-2002_08
Patent number
US06432881B1

Reaction notes

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