反应详情

温度

120 °C

Under an argon atmosphere, potassium carbonate (207 mg) was added to a solution of 4-iodophenol (220 mg) and 2-chloropyrimidine (114 mg) in DMF (1 ml), and the resulting mixture was stirred at 120° C. for 3 hours. The reaction solution was cooled to room temperature and saturated brine was added thereto, followed by extracting the resulting mixture with chloroform. Organic layer was washed with saturated brine and dried over anhydrous sodium sulfate. After removing anhydrous sodium sulfate by filtration, the filtrate was concentrated. The residue was purified by column chromatography (silica gel, eluent: hexane/ethyl acetate=3/1) to obtain 2-(4-iodophenoxy)pyrimidine (288 mg). NMR (HL, CDCl3): δ 6.97-7.00 (2H, m), 7.06 (1H, t, J=4.6 Hz), 7.73-7.75 (2H, m), 8.57 (2H, d, J=4.6 Hz)

1. temperatureThe reaction solution was cooled to room temperature
2. extractionby extracting the resulting mixture with chloroform
3. washOrganic layer was washed with saturated brine
4. dry with materialdried over anhydrous sodium sulfate
5. customAfter removing anhydrous sodium sulfate
6. filtrationby filtration
7. concentrationthe filtrate was concentrated
8. customThe residue was purified by column chromatography (silica gel, eluent: hexane/ethyl acetate=3/1)