反应详情

温度

60 °C

A 508 mg portion of 3,5-dimethylpyrazole-1-carboxamidine nitrate and 876 μl of diisopropylethylamine were added to a mixture of 328 mg of 2-(2-aminoethylamino)-4-(3-methylanilino)pyrimidine-5-carboxamide and THF, followed by stirring at 60° C. for one week. Water and ethyl acetate were added to the reaction mixture, and the water layer was concentrated under a reduced pressure. The resulting residue was washed with a mixed solution of methanol and ethyl acetate and then recrystallized from a mixed solvent of methanol and water to obtain 200 mg of 2-[(2-guanidinoethyl)amino]-4-(3-methylanilino)pyrimidine-5-carboxamide nitrate as colorless crystals.

1. concentrationthe water layer was concentrated under a reduced pressure
2. washThe resulting residue was washed with a mixed solution of methanol and ethyl acetate
3. customrecrystallized from a mixed solvent of methanol and water