Hydrochloric Acid → HCID 9885320, compound

HRID 2304460Notes

Reaction equation

HRID 2304460 reaction equation
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9](/[CH:12]=[CH:13]/[C:14]2[O:15][C:16]3[CH:22]=[CH:21][CH:20]=[CH:19][C:17]=3[N:18]=2)=[CH:8][CH:7]=1.[NH:23]1[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]1.Cl>>[N:23]1([CH2:2][CH2:3][CH2:4][O:5][C:6]2[CH:11]=[CH:10][C:9](/[CH:12]=[CH:13]/[C:14]3[O:15][C:16]4[CH:22]=[CH:21][CH:20]=[CH:19][C:17]=4[N:18]=3)=[CH:8][CH:7]=2)[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 8082PiperidineHCID 14146343HCID 14146343, compound

Product 1

HCID 9885320HCID 9885320, compoundYield 41%

Procedure

The procedure of Example 1 was followed starting with (C) of Example 1 (2.0 g, 6.4 mmol) and using piperidine in place of dibutylamine to produce 1.1 g, (41% yield) of the named compound as the HCl salt, mp 127°-128° C. IR(KBr): 3400,1600 cm−1. MS: 363(MH+). 1H NMR (CD3 OD): δ 7.89-6.81 (m, 10H), 4.24 (t, J=5.5 Hz, 2H), 2.65 (m, 6H), 1.75 (m, 8H).

Sources & evidence

ORD record
ord-90d7ed6073ac4d73a57fc01fca057a75
Source dataset
uspto-grants-2002_08
Patent number
US06436939B2

Reaction notes

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