反应详情

A mixture of 5-fluoro-3-methoxy-2-nitrophenol(0.56 g), acetonitrile(5 mL), potassium carbonate(0.46 g) and benzyl bromide(0.56 g) was stirred at reflux for 2 h. The cooled mixture was treated with water and ethyl acetate and the organic phase was separated, washed with brine, dried and evaporated to dryness. The residue was purified by flash chromatography eluting with increasingly polar mixtures of ethyl acetate and hexane to give the product (0.82 g), (m/e278, MH+).

1. temperatureat reflux for 2 h
2. customthe organic phase was separated
3. washwashed with brine
4. customdried
5. customevaporated to dryness
6. customThe residue was purified by flash chromatography
7. washeluting
8. temperaturewith increasingly polar mixtures of ethyl acetate and hexane