反应详情

温度

125 °C

A 600 ml autoclave containing a mixture of 1-ethenyl-cyclopentanol (172.0 g; 1.54 mol), isopropenyl methyl ether (218.8 g; 3.04 mol), triethylamine (1.65 ml) and 85% H3PO4 (0.72 ml) was pressurized with N2 at 2 bar and heated up to 125° C. An increase of the pressure to 7 bar was observed. After 14 hours stirring, the autoclave was cooled down to room temperature and depressurized. MTBE (1.5 l) was added to the mixture, washed with H2O (4×25 ml) until neutral pH, dried (MgSO4) and concentrated. Distillation (61° C./0.1 torr) yielded 161.3 g (69% yield) of 5-cyclopentylidenepentan-2-one.

1. additionA 600 ml autoclave containing
2. temperatureAn increase of the pressure to 7 bar
3. temperaturethe autoclave was cooled down to room temperature
4. washwashed with H2O (4×25 ml) until neutral pH
5. dry with materialdried (MgSO4)
6. concentrationconcentrated
7. distillationDistillation (61° C./0.1 torr)