Water → HCID 18433491, compound

HRID 2306246Notes

Reaction equation

HRID 2306246 reaction equation
[NH2:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.CCN(CC)CC.[C:19](OC(=O)C)(=[O:21])[CH3:20].O>C(Cl)Cl>[C:19]([N:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH:11]=[C:2]([NH2:1])[CH2:3]1)(=[O:21])[CH3:20]

Participants

6

Reactant 4

HCID 962WaterHCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 113753-Aminoquinoline

Product 1

HCID 18433491HCID 18433491, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3-Aminoquinoline (6.04 g, 41.89 mmol) and Et3N (5.85 mL, 41.89 mmol) were dissolved in CH2Cl2 (75 mL). Acetic anhydride (3.95 mL, 41.89 mmol) was added and reaction stirred at ambient temperature for 18 hours. The reaction mixture was poured into H2O and filtered. The filtered solid was dried in vacuo to yield the above-titled compound.

Workup

  1. customreaction
  2. filtrationfiltered
  3. customThe filtered solid was dried in vacuo

Sources & evidence

ORD record
ord-a645f7ab398d4c9daad443d5c79dcb7b
Source dataset
uspto-grants-2002_08
Patent number
US06441017B1

Reaction notes

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