反应详情

A mixture of 2-fluoro-cinnamic acid (83 mg), 1-(2-fluoro-5-morpholin-4-yl-phenyl)ethylamine, Preparation 25(112 mg), DMAP (61 mg), EDC.HCl (190 mg), and Et3N (202 mg) in CH2Cl2 (4 mL) was stirred for 16 hours. The crude product was purified by flash chromatography over silica gel (elution with 50% ethyl acetate in hexane) to give 150 mg of the title compound as a solid.

1. customThe crude product was purified by flash chromatography over silica gel (elution with 50% ethyl acetate in hexane)