反应详情

2-Bromopyridine (1.00 g), methyl 4-hydroxybenzenecarboxylate (1.92 g) and potassium carbonate (874.9 mg) were stirred at 150° C. for 6 hours. Aqueous 2 N sodium hydroxide solution (50 mL) was added to the reaction liquid, extracted with diethyl ether (100 mL), and the organic layer was washed with water (50 mL) and saturated saline water (50 mL) in that order, and then evaporated under reduced pressure to obtain a pale yellow residue. The resulting residue was purified through silica gel column chromatography (hexane/ethyl acetate=9/1 to 8/2) to obtain the entitled compound (208 mg) as a pale yellow solid.

1. extractionextracted with diethyl ether (100 mL)
2. washthe organic layer was washed with water (50 mL) and saturated saline water (50 mL) in that order
3. customevaporated under reduced pressure
4. customto obtain a pale yellow residue
5. customThe resulting residue was purified through silica gel column chromatography (hexane/ethyl acetate=9/1 to 8/2)