反应详情

To a solution of 2′-benzyloxy-6′-hydroxy-4-methylchalcone (0.69 g) in acetone (10 mL)-N,N-dimethylformamide (10 mL) were added potassium carbonate (0.41 g) and methyl bromoacetate (0.21 mL), and the mixture was stirred at room temperature overnight. The reaction mixture was poured into water, and the resulting mixture was extracted with diethyl ether. The extract was washed with water and dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure. The residue was dissolved in methanol (10 mL). To the solution was added 10% palladium-carbon powder (0.29 g), and the mixture was stirred at room temperature under a hydrogen atmosphere for 5 hours. Dichloromethane was added to the mixture, and the insoluble material was removed by filtration. The filtrate was concentrated under reduced pressure to give the title compound (0.58 g).

1. extractionthe resulting mixture was extracted with diethyl ether
2. washThe extract was washed with water
3. dry with materialdried over anhydrous magnesium sulfate
4. customthe solvent was removed under reduced pressure
5. dissolutionThe residue was dissolved in methanol (10 mL)
6. additionTo the solution was added 10% palladium-carbon powder (0.29 g)
7. stirringthe mixture was stirred at room temperature under a hydrogen atmosphere for 5 hours
8. additionDichloromethane was added to the mixture
9. customthe insoluble material was removed by filtration
10. concentrationThe filtrate was concentrated under reduced pressure