反应详情

A mixture of 3-[2-(4-acetylaminophenyl)ethyl]-4-hydroxybenzofuran (1.2 g) and n-propanol (4 mL)-5 mol/L aqueous sodium hydroxide solution (8 mL) was heated for ref lux overnight. The reaction mixture was cooled to room temperature. To the reaction mixture was added 2 mol/L hydrochloric acid (21 mL). The mixture was poured into a saturated aqueous sodium hydrogen carbonate solution, and the resulting mixture was extracted with ethylacetate. The extract was washed with brine, and dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure, and the residue was treated with ethyl acetate. The precipitated crystals were collected by filtration and dried under reduced pressure to give the title compound (0.51 g).

1. temperaturewas heated for ref lux overnight
2. extractionthe resulting mixture was extracted with ethylacetate
3. washThe extract was washed with brine
4. dry with materialdried over anhydrous sodium sulfate
5. customThe solvent was removed under reduced pressure
6. additionthe residue was treated with ethyl acetate
7. filtrationThe precipitated crystals were collected by filtration
8. customdried under reduced pressure