Tetrahydrofuran → 6-methoxy-N-(3-(2-methyl-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-yl)pyridin-3-amine
Reaction equation
[CH2:43]1[O:44][CH2:45][CH2:46][CH2:47]1.[CH3:24][O:25][c:26]1[cH:27][cH:28][c:29]([NH2:32])[cH:30][n:31]1.[CH3:34][Si:35]([N-:36][Si:37]([CH3:38])([CH3:39])[CH3:40])([CH3:41])[CH3:42].[F:1][c:2]1[n:3][cH:4][cH:5][cH:6][c:7]1-[c:8]1[c:9]2[n:10][cH:11][n:12]([CH:18]3[O:19][CH2:20][CH2:21][CH2:22][CH2:23]3)[c:13]2[n:14][c:15]([CH3:17])[n:16]1.[Li+:33]>>[c:2]1([NH:32][c:29]2[cH:28][cH:27][c:26]([O:25][CH3:24])[n:31][cH:30]2)[n:3][cH:4][cH:5][cH:6][c:7]1-[c:8]1[c:9]2[n:10][cH:11][n:12]([CH:18]3[O:19][CH2:20][CH2:21][CH2:22][CH2:23]3)[c:13]2[n:14][c:15]([CH3:17])[n:16]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-474579afbc2d40c6bf9f748df4b73aae
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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