Tetrahydrofuran → 4-chloro-N-({4-chloro-3-[(3-chloro-5-methylphenyl)oxy]-2-fluorophenyl}methyl)-1-({[2-(trimethylsilyl)ethyl]oxy}methyl)-1H-imidazole-5-carboxamide
Reaction equation
[Br:1][c:2]1[cH:3][c:4]([O:9][c:10]2[c:11]([F:35])[c:12]([CH2:17][NH:18][C:19](=[O:20])[c:21]3[c:22]([Cl:34])[n:23][cH:24][n:25]3[CH2:26][O:27][CH2:28][CH2:29][Si:30]([CH3:31])([CH3:32])[CH3:33])[cH:13][cH:14][c:15]2[Cl:16])[cH:5][c:6]([Cl:8])[cH:7]1.[CH2:48]1[O:49][CH2:50][CH2:51][CH2:52]1.[CH3:36][CH:37]([CH2:38][AlH:39][CH2:40][CH:41]([CH3:42])[CH3:43])[CH3:44].[CH3:45][Zn:46][CH3:47].[CH3:53][CH2:54][O:55][C:56]([CH3:57])=[O:58]>>[c:2]1([CH3:36])[cH:3][c:4]([O:9][c:10]2[c:11]([F:35])[c:12]([CH2:17][NH:18][C:19](=[O:20])[c:21]3[c:22]([Cl:34])[n:23][cH:24][n:25]3[CH2:26][O:27][CH2:28][CH2:29][Si:30]([CH3:31])([CH3:32])[CH3:33])[cH:13][cH:14][c:15]2[Cl:16])[cH:5][c:6]([Cl:8])[cH:7]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-49fa51781ac445efa8f3fd74e56c1914
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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