反应详情

2-Acetyl-4-phenylcyclohexanone, 1.68 g, 0.73 g of cyanoacetamide and a small quantity of piperidine were mixed with 10 ml of ethanol followed by heating to reflux for 2 hours. After cooling, the precipitated crystals were taken out by filtration and purified to give 1.5 g of 4-cyano-2,3,5,6,7,8-hexahydro-1-methyl-3-oxo-7-phenylisoquinoline.

1. temperatureby heating
2. temperatureto reflux for 2 hours
3. temperatureAfter cooling
4. filtrationthe precipitated crystals were taken out by filtration
5. custompurified