Cyanoacetamide → HCID 13632728, compound

HRID 231223Notes

Reaction equation

HRID 231223 reaction equation
[C:1]([CH:4]1[CH2:9][CH:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH2:7][CH2:6][C:5]1=O)(=O)[CH3:2].[C:17]([CH2:19][C:20]([NH2:22])=[O:21])#[N:18].N1CCCCC1>C(O)C>[C:17]([C:19]1[C:20](=[O:21])[NH:22][C:1]([CH3:2])=[C:4]2[C:5]=1[CH2:6][CH2:7][CH:8]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH2:9]2)#[N:18]

Participants

5

Reactant 3

HCID 7898CyanoacetamideHCID 8082PiperidineHCID 13632725HCID 13632725, compound

Product 1

HCID 13632728HCID 13632728, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-Acetyl-4-phenylcyclohexanone, 1.68 g, 0.73 g of cyanoacetamide and a small quantity of piperidine were mixed with 10 ml of ethanol followed by heating to reflux for 2 hours. After cooling, the precipitated crystals were taken out by filtration and purified to give 1.5 g of 4-cyano-2,3,5,6,7,8-hexahydro-1-methyl-3-oxo-7-phenylisoquinoline.

Workup

  1. temperatureby heating
  2. temperatureto reflux for 2 hours
  3. temperatureAfter cooling
  4. filtrationthe precipitated crystals were taken out by filtration
  5. custompurified

Sources & evidence

ORD record
ord-5a55308ca9754ff68b1b8fdce636e4c4
Source dataset
uspto-grants-1989_07
Patent number
US04845228

Reaction notes

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