Diisopropylamine → N-[3-(5-Bromopyridin-2-yl)prop-2-ynyl]acetamide

HRID 2312625Notes

Reaction equation

HRID 2312625 reaction equation
[Br:1][c:2]1[n:3][cH:4][c:5]([Br:8])[cH:6][cH:7]1.[C:9]([CH3:10])(=[O:11])[NH:12][CH2:13][C:14]#[CH:15].[CH3:23][CH2:24][O:25][C:26](=[O:27])[CH3:28].[CH:16]([NH:17][CH:18]([CH3:19])[CH3:20])([CH3:21])[CH3:22].[Cu:29][I:30].[Pd:31]([Cl:32])[Cl:33].[c:34]1([P:35]([c:36]2[cH:37][cH:38][cH:39][cH:40][cH:41]2)[c:42]2[cH:43][cH:44][cH:45][cH:46][cH:47]2)[cH:48][cH:49][cH:50][cH:51][cH:52]1.[c:53]1([P:54]([c:55]2[cH:56][cH:57][cH:58][cH:59][cH:60]2)[c:61]2[cH:62][cH:63][cH:64][cH:65][cH:66]2)[cH:67][cH:68][cH:69][cH:70][cH:71]1>>[c:2]1([C:15]#[C:14][CH2:13][NH:12][C:9]([CH3:10])=[O:11])[n:3][cH:4][c:5]([Br:8])[cH:6][cH:7]1

Participants

8

Reactant 7

HCID 7912DiisopropylamineHCID 8857Ethyl AcetateHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 693532,5-DibromopyridineHCID 24079665881-41-6

Product 1

HCID 12991110N-[3-(5-Bromopyridin-2-yl)prop-2-ynyl]acetamide

Sources & evidence

ORD record
ord-079e5b2082114c99916254048b6c87ce
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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