Acetate → (6-Cyclopropyl-2-phenyl-imidazo[1,2-a]pyridin-7-yl)-carbamic acid tert-butyl ester

HRID 2313524Notes

Reaction equation

HRID 2313524 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][c:8]1[cH:9][c:10]2[n:11]([cH:12][c:13]1[Br:14])[cH:15][c:16](-[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[n:17]2)=[O:24].[CH3:58][CH2:59][O:60][C:61](=[O:62])[CH3:63].[CH3:74][c:75]1[cH:76][cH:77][cH:78][cH:79][cH:80]1.[CH:25]1([B:28]([OH:29])[OH:30])[CH2:26][CH2:27]1.[CH:39]1([P:40]([CH:41]2[CH2:42][CH2:43][CH2:44][CH2:45][CH2:46]2)[CH:47]2[CH2:48][CH2:49][CH2:50][CH2:51][CH2:52]2)[CH2:53][CH2:54][CH2:55][CH2:56][CH2:57]1.[K+:36].[K+:37].[K+:38].[O-:65][C:66]([CH3:67])=[O:68].[O-:69][C:70]([CH3:71])=[O:72].[OH2:73].[P:31]([O-:32])([O-:33])([O-:34])=[O:35].[Pd+2:64]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][c:8]1[cH:9][c:10]2[n:11]([cH:12][c:13]1[CH:25]1[CH2:26][CH2:27]1)[cH:15][c:16](-[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[n:17]2)=[O:24]

Participants

11

Reactant 10

HCID 175Acetate2×HCID 813Potassium Cation3×HCID 962WaterHCID 1061PhosphateHCID 1140TolueneHCID 8857Ethyl AcetateHCID 75806TricyclohexylphosphineHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 2760897Cyclopropylboronic acidHCID 67041813(6-Bromo-2-phenyl-imidazo[1,2-a]pyridin-7-yl)-carbamic acid tert-butyl ester

Product 1

HCID 67041799(6-Cyclopropyl-2-phenyl-imidazo[1,2-a]pyridin-7-yl)-carbamic acid tert-butyl ester

Sources & evidence

ORD record
ord-0381062c240543139d824da72d340d4f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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