Sodium ethoxide → 2-Bromo-1-(ethoxymethyl)-4-fluorobenzene

HRID 231447Notes

Reaction equation

HRID 231447 reaction equation
[Br:1][C:2]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:3]=1[CH2:4]Br.[O-:11][CH2:12][CH3:13].[Na+]>C(O)C.O1CCCC1>[Br:1][C:2]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:3]=1[CH2:4][O:11][CH2:12][CH3:13]

Participants

5

Reactant 2

HCID 2723922Sodium ethoxideHCID 107069772-Bromo-1-(bromomethyl)-4-fluorobenzene

Product 1

HCID 200323562-Bromo-1-(ethoxymethyl)-4-fluorobenzene

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

By the method of Example 1, Step A, 10.9 g (0.041 mole) of 2-bromo-4-fluorobenzyl bromide and 18.2 ml of a 21% by weight solution of sodium ethoxide in ethanol were reacted in 50 ml of tetrahydrofuran, yielding 7.18 g of ethyl 2-bromo-4-fluorobenzyl ether.

Sources & evidence

ORD record
ord-c50c1de3d01844b7ba0c5d3980a95b3f
Source dataset
uspto-grants-1989_07
Patent number
US04846882

Reaction notes

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