Phosphorus oxychloride → HCID 20032422, compound

HRID 231457Notes

Reaction equation

HRID 231457 reaction equation
O=P(Cl)(Cl)Cl.[CH2:6]([C:8]1[CH:13]=[CH:12][C:11]([CH:14]2[CH2:19][CH2:18][CH:17]([CH2:20][CH2:21][CH3:22])[CH2:16][CH:15]2[C:23]([NH2:25])=O)=[CH:10][CH:9]=1)[CH3:7]>CN(C=O)C>[CH2:6]([C:8]1[CH:13]=[CH:12][C:11]([CH:14]2[CH2:19][CH2:18][CH:17]([CH2:20][CH2:21][CH3:22])[CH2:16][CH:15]2[C:23]#[N:25])=[CH:10][CH:9]=1)[CH3:7]

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 54547003HCID 54547003, compound

Product 1

HCID 20032422HCID 20032422, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

65 g of POCl3 are added dropwise with stirring at 50° to a solution of 24 g of 2-(p-ethylphenyl)-5-n-propylcyclohexanecarboxamide in 500 ml of DMF. After further stirring for one hour the reaction mixture is poured onto ice and worked up as customary to give 2-(p-ethylphenyl)-5-n-propylcyclohexanecarbonitrile.

Workup

  1. additionis poured onto ice

Sources & evidence

ORD record
ord-24954e7dbbfd46eead6ba1b4c3264c88
Source dataset
uspto-grants-1989_07
Patent number
US04846998

Reaction notes

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