Acetonitrile → {5-({[4-(Methyloxy)phenyl]methyl}oxy)-4-[(trimethylsilyl)ethynyl]-2-pyridinyl}methyl acetate

HRID 2315141Notes

Reaction equation

HRID 2315141 reaction equation
[C:1]([CH3:2])(=[O:3])[O:4][CH2:5][c:6]1[n:7][cH:8][c:9]([O:20][CH2:21][c:22]2[cH:23][cH:24][c:25]([O:28][CH3:29])[cH:26][cH:27]2)[c:10]([O:12][S:13]([C:14]([F:15])([F:16])[F:17])(=[O:18])=[O:19])[cH:11]1.[CH3:30][CH2:31][N:32]([CH2:33][CH3:34])[CH2:35][CH3:36].[CH3:37][Si:38]([CH3:39])([CH3:40])[C:41]#[CH:42].[CH3:43][C:44]#[N:45].[Cu:46][I:47]>>[C:1]([CH3:2])(=[O:3])[O:4][CH2:5][c:6]1[n:7][cH:8][c:9]([O:20][CH2:21][c:22]2[cH:23][cH:24][c:25]([O:28][CH3:29])[cH:26][cH:27]2)[c:10]([C:42]#[C:41][Si:38]([CH3:37])([CH3:39])[CH3:40])[cH:11]1

Participants

6

Reactant 5

HCID 6342AcetonitrileHCID 8471TriethylamineHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 66111TrimethylsilylacetyleneHCID 57423118(5-((4-Methoxybenzyl)oxy)-4-(((trifluoromethyl)sulfonyl)oxy)pyridin-2-yl)methyl acetate

Product 1

HCID 57423117{5-({[4-(Methyloxy)phenyl]methyl}oxy)-4-[(trimethylsilyl)ethynyl]-2-pyridinyl}methyl acetate

Sources & evidence

ORD record
ord-b0ec9491568b491f83cc8387e45fff86
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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