Sulfuric Acid → HCID 88521943, compound

HRID 231676Notes

Reaction equation

HRID 231676 reaction equation
C(OC(=O)C)(=O)C.[C:8]([C:10]1[CH:15]=[CH:14][C:13]([S:16][C:17]2[S:18][CH:19]=[CH:20][CH:21]=2)=[C:12]([F:22])[CH:11]=1)#[N:9].[S:23](=O)(=[O:26])([OH:25])[OH:24].C([O-])(=O)C.[K+:32]>C(OCC)(=O)C.C(O)C>[K+:32].[C:8]([C:10]1[CH:15]=[CH:14][C:13]([S:16][C:17]2[S:18][C:19]([S:23]([O-:26])(=[O:25])=[O:24])=[CH:20][CH:21]=2)=[C:12]([F:22])[CH:11]=1)#[N:9]

Participants

7

Reactant 4

HCID 1118Sulfuric AcidHCID 7918Acetic AnhydrideHCID 517044Potassium AcetateHCID 20033719HCID 20033719, compound

Product 1

HCID 88521943HCID 88521943, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8857Ethyl AcetateSolvent2×

Procedure

Acetic anhydride (7.34 g, 0.072 mol) was added to (4-cyano-2-fluorophenylthio)thiophene (8.46 g, 0.036 mol) in 200 ml ethyl acetate at 0° C. A cooled solution of sulfuric acid (3.88 g, 0.0395 mol) and ethyl acetate (10 ml) was added dropwise and allowed to stir at room temperature overnight. After cooling to 0° C. potassium acetate (4.23 g, 0.043 mol) in a minimum amount of ethanol was added slowly. A white solid (11.70 g) was collected after stirring one hour.

Workup

  1. additionwas added slowly
  2. customA white solid (11.70 g) was collected
  3. stirringafter stirring one hour

Sources & evidence

ORD record
ord-c7bcb065a32046ad98f62438be6259e6
Source dataset
uspto-grants-1989_07
Patent number
US04847289

Reaction notes

Loading…