Tetrahydrofuran → 4-(6-((2H-pyran-4(3H,5H,6H)-ylidene)methyl)-2-chloropyrido[3,2-d]pyrimidin-4-yl)morpholine

HRID 2317714Notes

Reaction equation

HRID 2317714 reaction equation
[CH2:40]1[O:41][CH2:42][CH2:43][CH2:44]1.[CH:25]([N-:26][CH:27]([CH3:28])[CH3:29])([CH3:30])[CH3:31].[Cl:1][c:2]1[n:3][c:4]([N:19]2[CH2:20][CH2:21][O:22][CH2:23][CH2:24]2)[c:5]2[c:6]([n:7]1)[cH:8][cH:9][c:10]([CH2:12][P:13](=[O:14])([O:15][CH3:16])[O:17][CH3:18])[n:11]2.[Li+:32].[O:33]1[CH2:34][CH2:35][C:36](=[O:39])[CH2:37][CH2:38]1>>[Cl:1][c:2]1[n:3][c:4]([N:19]2[CH2:20][CH2:21][O:22][CH2:23][CH2:24]2)[c:5]2[c:6]([n:7]1)[cH:8][cH:9][c:10]([CH:12]=[C:36]1[CH2:35][CH2:34][O:33][CH2:38][CH2:37]1)[n:11]2

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 121599Tetrahydro-4H-pyran-4-oneHCID 5062348DiisopropylamideHCID 58405032Dimethyl (2-chloro-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methylphosphonate

Product 1

HCID 584050234-(6-((2H-pyran-4(3H,5H,6H)-ylidene)methyl)-2-chloropyrido[3,2-d]pyrimidin-4-yl)morpholine

Sources & evidence

ORD record
ord-399409d83dff4e0894be138ff1783639
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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