Pyrazole → HCID 10680030, compound

HRID 231788Notes

Reaction equation

HRID 231788 reaction equation
Cl[C:2]1[CH:7]=[C:6](Cl)[N:5]=[CH:4][N:3]=1.[NH:9]1[CH:13]=[CH:12][CH:11]=[N:10]1>O1CCCC1>[N:9]1([C:4]2[N:5]=[C:6]([N:9]3[CH:13]=[CH:12][CH:11]=[N:10]3)[CH:7]=[CH:2][N:3]=2)[CH:13]=[CH:12][CH:11]=[N:10]1

Participants

4

Reactant 2

HCID 1048PyrazoleHCID 709434,6-Dichloropyrimidine

Product 1

HCID 10680030HCID 10680030, compoundYield 84.4%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In anhydrous tetrahydrofuran, 149 mg of 4,6-dichloropyrimidine was substituted with 136 mg of pyrazole. The reaction mixture was treated according to the procedure of Example 1 to yield 179 mg of 2,4-bis(1-pyrazolyl)pyrimidine, recrystallized from n-hexane, the compound had a melting point of 152°-153° C.

Workup

  1. additionThe reaction mixture was treated

Sources & evidence

ORD record
ord-fc07d3ffe552458fae90f246f23e6390
Source dataset
uspto-grants-1989_07
Patent number
US04849424

Reaction notes

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