Hydrochloric Acid → 4-(4-Chloro-2-fluoroanilino)-7-((2-cyano4-pyridyl)methoxy)-6-methoxyquinazoline
Reaction equation
[C:34](=[O:35])([O-:36])[O-:37].[Cl:1][c:2]1[cH:3][c:4]([F:22])[c:5]([NH:6][c:7]2[n:8][cH:9][n:10][c:11]3[cH:12][c:13]([OH:19])[c:14]([O:17][CH3:18])[cH:15][c:16]23)[cH:20][cH:21]1.[Cl:24][CH2:25][c:26]1[cH:27][c:28]([C:32]#[N:33])[n:29][cH:30][cH:31]1.[ClH:23].[K+:38].[K+:39].[O:41]=[CH:42][N:43]([CH3:44])[CH3:45].[OH2:40]>>[Cl:1][c:2]1[cH:3][c:4]([F:22])[c:5]([NH:6][c:7]2[n:8][cH:9][n:10][c:11]3[cH:12][c:13]([O:19][CH2:25][c:26]4[cH:27][c:28]([C:32]#[N:33])[n:29][cH:30][cH:31]4)[c:14]([O:17][CH3:18])[cH:15][c:16]23)[cH:20][cH:21]1Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-116fcbc4c82c4cdb80f11efceef801f2
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
Loading…