Potassium Cation → 4-[4-(4-Bromomethylbenzyloxy)phenyl]-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxypropyl]azetidin-2-one

HRID 2321410Notes

Reaction equation

HRID 2321410 reaction equation
[Br:31][CH2:32][c:33]1[cH:34][cH:35][c:36]([CH2:39][Br:40])[cH:37][cH:38]1.[C:41](=[O:42])([O-:43])[O-:44].[CH3:47][N:48]([CH3:49])[CH:50]=[O:51].[CH3:52][CH2:53][O:54][C:55](=[O:56])[CH3:57].[F:1][c:2]1[cH:3][cH:4][c:5]([N:8]2[C:9](=[O:30])[CH:10]([CH2:19][CH2:20][CH:21]([OH:22])[c:23]3[cH:24][cH:25][c:26]([F:29])[cH:27][cH:28]3)[CH:11]2[c:12]2[cH:13][cH:14][c:15]([OH:18])[cH:16][cH:17]2)[cH:6][cH:7]1.[K+:45].[K+:46]>>[F:1][c:2]1[cH:3][cH:4][c:5]([N:8]2[C:9](=[O:30])[CH:10]([CH2:19][CH2:20][CH:21]([OH:22])[c:23]3[cH:24][cH:25][c:26]([F:29])[cH:27][cH:28]3)[CH:11]2[c:12]2[cH:13][cH:14][c:15]([O:18][CH2:39][c:36]3[cH:35][cH:34][c:33]([CH2:32][Br:31])[cH:38][cH:37]3)[cH:16][cH:17]2)[cH:6][cH:7]1

Participants

7

Reactant 6

HCID 813Potassium Cation2×HCID 6228DimethylformamideHCID 8857Ethyl AcetateHCID 19660Carbonate IonHCID 693351,4-Bis(bromomethyl)benzeneHCID 49799421-(4-Fluorophenyl)-3-(3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one

Product 1

HCID 210831904-[4-(4-Bromomethylbenzyloxy)phenyl]-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxypropyl]azetidin-2-one

Sources & evidence

ORD record
ord-a493fd7cfc3048e6812a378f5eec181e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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