Hydrochloric Acid → 1,1-Dimethylethyl N-((6-chloro-4-hydroxy-2-oxo-2',3',5',6'-tetrahydro-spiro[naphthalene-1,4'-pyran]-3-yl)carbonyl)-2-methylalaninate

HRID 2321964Notes

Reaction equation

HRID 2321964 reaction equation
[CH2:24]([N:25]([CH:26]([CH3:27])[CH3:28])[CH:29]([CH3:30])[CH3:31])[CH3:32].[CH2:45]1[O:46][CH2:47][CH2:48][O:49][CH2:50]1.[CH3:51][CH2:52][O:53][C:54]([CH3:55])=[O:56].[Cl:1][c:2]1[cH:3][c:4]2[c:9]([cH:10][cH:11]1)[C:8]1([C:7](=[O:17])[C:6]([C:18](=[O:19])[O:20][CH2:21][CH3:22])=[C:5]2[OH:23])[CH2:12][CH2:13][O:14][CH2:15][CH2:16]1.[ClH:33].[NH2:34][C:35]([C:36](=[O:37])[O:38][C:39]([CH3:40])([CH3:41])[CH3:42])([CH3:43])[CH3:44]>>[Cl:1][c:2]1[cH:3][c:4]2[c:9]([cH:10][cH:11]1)[C:8]1([C:7](=[O:17])[C:6]([C:18](=[O:19])[NH:34][C:35]([C:36](=[O:37])[O:38][C:39]([CH3:40])([CH3:41])[CH3:42])([CH3:43])[CH3:44])=[C:5]2[OH:23])[CH2:12][CH2:13][O:14][CH2:15][CH2:16]1

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 312751,4-DioxaneHCID 81531DiisopropylethylamineHCID 7019940tert-Butyl 2-methylalaninateHCID 67099777HCID 67099777, compound

Product 1

HCID 670998271,1-Dimethylethyl N-((6-chloro-4-hydroxy-2-oxo-2',3',5',6'-tetrahydro-spiro[naphthalene-1,4'-pyran]-3-yl)carbonyl)-2-methylalaninate

Sources & evidence

ORD record
ord-03e0ad0b855248fca01e612472695546
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

Loading…