反应详情

In 3 ml of anhydrous N,N-dimethylformamide was dissolved 220 mg of (4R)-4-phenylacetamido-3-isoxazolidinone. To the solution were added, under ice-cooling and stirring, 60 mg of sodium hydride (50% mineral oil) and 0.5 ml of anhydrous N,N-dimethylformamide solution dissolving 220 mg of the Compound (26) obtained in Example 26. The reaction solution was stirred for 69 minutes under ice-cooling, which was then poured into a mixture of ethyl acetate and water. The ethyl acetate layer was taken, washed with water and dried (Na2SO4). The solvent was evaporated off, and the residue was subjected to a silica gel column chromatography, followed by elution with hexane-ethyl acetate (2:1→2:3) to give 32 mg of the subject Compound (30) as colorless oil.

1. additionTo the solution were added, under ice-
2. temperaturecooling
3. stirringThe reaction solution was stirred for 69 minutes under ice-
4. temperaturecooling
5. washwashed with water
6. dry with materialdried (Na2SO4)
7. customThe solvent was evaporated off
8. washfollowed by elution with hexane-ethyl acetate (2:1→2:3)