Ammonium → Tert-butyl 2-[3-acetyl-4-[(3,5-difluorophenyl)methyl]-2,2-dimethyl-1,3-oxazolidin-5-yl]-4-hydroxy-4-(trifluoromethyl)pyrrolidine-1-carboxylate

HRID 2322203Notes

Reaction equation

HRID 2322203 reaction equation
[C:9]([CH3:10])([CH3:11])([CH3:12])[O:13][C:14](=[O:15])[N:16]1[CH:17]([CH:22]2[CH:23]([CH2:32][c:33]3[cH:34][c:35]([F:40])[cH:36][c:37]([F:39])[cH:38]3)[N:24]([C:29]([CH3:30])=[O:31])[C:25]([CH3:27])([CH3:28])[O:26]2)[CH2:18][C:19](=[O:21])[CH2:20]1.[CH3:42][CH2:43][CH2:44][CH2:45][N+:46]([CH2:47][CH2:48][CH2:49][CH3:50])([CH2:51][CH2:52][CH2:53][CH3:54])[CH2:55][CH2:56][CH2:57][CH3:58].[CH3:66][CH2:67][O:68][C:69](=[O:70])[CH3:71].[Cl-:59].[F-:41].[F:1][C:2]([F:3])([F:4])[Si:5]([CH3:6])([CH3:7])[CH3:8].[NH4+:60].[O:61]1[CH2:62][CH2:63][CH2:64][CH2:65]1.[OH2:72]>>[F:1][C:2]([F:3])([F:4])[C:19]1([OH:21])[CH2:18][CH:17]([CH:22]2[CH:23]([CH2:32][c:33]3[cH:34][c:35]([F:40])[cH:36][c:37]([F:39])[cH:38]3)[N:24]([C:29]([CH3:30])=[O:31])[C:25]([CH3:27])([CH3:28])[O:26]2)[N:16]([C:14]([O:13][C:9]([CH3:10])([CH3:11])[CH3:12])=[O:15])[CH2:20]1

Participants

10

Reactant 9

HCID 223AmmoniumHCID 312ChlorideHCID 962WaterHCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 16028TetrabutylammoniumHCID 28179Fluoride IonHCID 552549(Trifluoromethyl)trimethylsilaneHCID 178473758HCID 178473758, compound

Product 1

HCID 77558630Tert-butyl 2-[3-acetyl-4-[(3,5-difluorophenyl)methyl]-2,2-dimethyl-1,3-oxazolidin-5-yl]-4-hydroxy-4-(trifluoromethyl)pyrrolidine-1-carboxylate

Sources & evidence

ORD record
ord-ab40cd25848746b092a35a4e182d9dd3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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