Ammonia → HCID 14555604, compound

HRID 232316Notes

Reaction equation

HRID 232316 reaction equation
[CH3:1][CH:2]([O:11][C:12]1[CH:17]=[CH:16][C:15]([NH2:18])=[CH:14][CH:13]=1)[CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][O:8][CH2:7][CH2:6]1.[NH3:19].[CH:20]([CH:22]=O)=O.[CH2:24]=O>C(O)CC.CC(O)C>[CH3:1][CH:2]([O:11][C:12]1[CH:13]=[CH:14][C:15]([N:18]2[CH:22]=[CH:20][N:19]=[CH:24]2)=[CH:16][CH:17]=1)[CH2:3][CH2:4][N:5]1[CH2:6][CH2:7][O:8][CH2:9][CH2:10]1

Participants

7

Reactant 4

HCID 222AmmoniaHCID 712FormaldehydeHCID 7860GlyoxalHCID 14555603HCID 14555603, compound

Product 1

HCID 14555604HCID 14555604, compound

Reagents, catalysts & solvents 2

HCID 10311-PropanolSolventHCID 3776IsopropanolSolvent

Procedure

A mixture of 25.4 g (0.1 mol) of 4-[1-methyl-3-(morpholin-4-yl)propoxy]benzenamine, 6.8 g of 25% aqueous ammonia, and 10 mL of 2-propanol, and a mixture of 5.8 (0.1 mol) of glyoxal and 7.5 (0.1 mol) of 40% aqueous formaldehyde are simultaneously added into 20 mL of 1-propanol in the course of 30 minutes at 80° C. Monitor the reaction by thin-layer chromatography. Upon completion remove the solvent in vacuo to obtain the title compound.

Workup

  1. customMonitor the reaction by thin-layer chromatography
  2. customUpon completion remove the solvent in vacuo

Sources & evidence

ORD record
ord-4fa1e59688b143c9b78d8b058eef37fc
Source dataset
uspto-grants-1989_07
Patent number
US04851526

Reaction notes

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